Genetic, antimicrobial resistance profile and mortality rates of Acinetobacter baumannii infection in Brazil: A systematic review

The increase of multidrug-resistant bacteria - including Acinetobacter baumannii (A. baumannii) has been reported globally. aim this systematic review was to determine the risk factors A. infection, its resistance profile, reservoirs and mortality rates in Brazil. Data from over 3,000 patients were included. Results suggested that is widely transmitted Brazil endemic clones ST1, ST15, ST 25, ST79, ST162 ST730 most reported; also, blaOXA23, blaOXA51 blaOXA143 common resistant genes. for infectionincluded procedure using invasive devices, previous antibiotic therapy, hemodialysis, comorbidities higher scores on Sequential Organ Failure Assessment (SOFA). Two out five studies identified multidrug polymyxin. Mortality varied between 43.7% 81%, except ST25 strain which there a 100% rate. associated with sepsis, respiratory septic shock, old age (>60 years) administration norepinephrine. Nonetheless, highlights need more data infectionacross support public policies aiming control prevent dissemination bacteria.